Examing white adipose tissue remodelling at single cell level
We generated high quality single cell- and single nucleus-Sequencing dataset and discloses the multiplicited cell-cell communications within the white adipose tissue in response to low temperature stimulation.
Characterizing the negative regulator of adipose browning
Using our unique animal model, we identified androgen recepto (AR) as the most potent negative regulator of the gene Prdm16, a fate determinating factor for brown and beige adipocytes.
Lactate is a signalling metabolite potentiating chronic inflammation
We discovered in obese adipose tissue, the adipocytes secretes accessive amounts of lactate, which acts as a signling metabolite to arouse the local and systemic inflammation.